NCT02333448

Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in Invasive Candidiasis.

Diagnostic Value of PCR Genetic Amplification and Mannan Antigenemia Coupled With Antimannan Antibodies in Intensive Care Patients With Suspected Invasive Candidiasis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study consists in taking 4 tubes of blood at different times over a period of 10 days, via a catheter (central venous or arterial catheter) already in place in the usual therapeutic management. These samples will make it possible to measure blood levels of certain markers specific to invasive candidiasis. PCR will be used to quantify fungal load precisely, that is to say the quantity of yeast present in the blood and to monitor this quantity over time. These samples will be transferred to a specialized unit and stored for a maximum of three years for use at the end of the study.

Conditions

• Invasive Candidiasis; Treatment With Echinocandin

Interventions

Type	Name	Description
BIOLOGICAL	Blood sample taken on the day the treatment is initiated
BIOLOGICAL	Blood sample taken on day 3 after initiation of treatment
BIOLOGICAL	Blood sample taken on day 5 after initiation of
BIOLOGICAL	Blood sample taken on day 7 after initiation of treatment
BIOLOGICAL	Blood sample taken on day 10 after initiation of treatment

Timeline

• Start date: 2015-06-12
• Primary completion: 2019-09-17
• Completion: 2019-09-17
• First posted: 2015-01-07
• Last updated: 2024-02-20

Locations

1 site across 1 country: France