NCT02331589

Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Chuncheon Sacred Heart Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Background: Korea red ginseng (KRG) has anti-carcinogenic activity, anti-oxidant activity, and cancer related anti-fatigue. Methods: Seventy five patients with non-alcoholic hepatitis were prospectively randomized to receive 3 weeks of KRG or placebo. Liver function test, pro-inflammatory cytokines, adiponectin, fatigue severity scale, and antioxidant activity were check and compared.

Detailed description

Fatigue Severity Scale We used to be KRUPP's fatigue severity scale. The survey has nine questions as following: (1) my motivation is lower, when I am fatigued (2) exercise brings on my fatigue (3) I am easily fatigued (4) fatigue interferes with my physical functioning (5) fatigue causes frequent problems for me (6) my fatigue prevents sustained physical functioning (7) fatigue interferes with carrying out certain duties and responsibilities (8) fatigue is among my 3 most disabling symptoms (9) fatigue interferes with my work, family, or social life. All subjects scored each question on a 7-point scale (1 = strongly disagree to 4 = neither disagree nor agree to 7 = strongly agree). All fatigue severity scale calculated and collected by one research nurse (C.W.K) in the Department of Internal Medicine.

Conditions

• Fatigue

Interventions

Type	Name	Description
DRUG	KRG (Korea Red ginseng)	3 weeks of KRG capsule (3,000 mg/day)
DRUG	Placebo (for KRG)	Placebos with same shape and size were manufactured and at Korea Ginseng Corporation

Timeline

• Start date: 2011-08-01
• Primary completion: 2012-04-01
• Completion: 2012-04-01
• First posted: 2015-01-06
• Last updated: 2015-02-10
• Results posted: 2015-02-10