NCT02328469

Aseptic Meningoencephalitis in Slovenia

Prospective Study of the Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: University Medical Centre Ljubljana · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main objective of this study is: * to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia * to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis * to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with tick-borne encephalitis and Lyme neuroborreliosis

Conditions

• Aseptic Meningitis

Interventions

Type	Name	Description
DRUG	symptomatic therapy	patients will receive symptomatic therapy with antipyretics, analgetics, antiemetics and parenteral hydration: metamizole, paracetamol, thiethylperazine, saline
DRUG	Ceftriaxone or Doxycycline	beside symptomatic therapy (metamizole, paracetamol, thiethylperazine, saline), patients with proven or probable Lyme neuroborreliosis will be treated with ceftriaxone 2 g intravenously once daily for 14 days OR doxycycline 100 mg orally twice daily for 14 days
OTHER	questionnaire	Control subjects will be asked to answer a questionnaire asking about the presence and frequency of nonspecific symptoms.
DRUG	Acyclovir	Patients will be treated with intravenous acyclovir 10 mg per kg three times daily for 14 to 21 days.

Timeline

• Start date: 2014-06-01
• Primary completion: 2020-06-01
• Completion: 2020-06-01
• First posted: 2014-12-31
• Last updated: 2018-05-04

Locations

2 sites across 1 country: Slovenia