NCT02327728

Comparison of Different Botulinum Toxin A Injection Patterns in the Treatment of Blepharospasm

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: YangHui · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the efficacy of different botulinum toxin A injection patterns in treating benign essential blepharospasm and to compare their influence on condition of eye surface .

Detailed description

The authors performed a prospective double-blinded randomised clinical trial of 60 patients with an established diagnosis of benign essential blepharospasm from February 2013 to December 2015. Patients received a full injection pattern of 5 sites on one eye and a medial lower eyelid waived injection pattern of 4 sites on the other eye randomly. They were surveyed on ocular surface disease index (OSDI), Jankovic rating scale (JRS), blepharospasm disability index (BSDI) prior to injection and 1week, 1month and 3 months after injection. At these time points, closure of the eyelid, tear break up time (BUT), Schirmer test Ｉ, and lower lid tear meniscus height (TMH) were also measured.

Conditions

• Blepharospasm

Interventions

Type	Name	Description
PROCEDURE	Botulinum toxin A injection (5 sites: 12.5U)
PROCEDURE	Botulinum toxin A injection (4 sites: 10U)
DRUG	Botulinum toxin A 12.5U
DRUG	Botulinum toxin A 10U

Timeline

• Start date: 2013-02-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2014-12-30
• Last updated: 2014-12-30

Locations

1 site across 1 country: China