NCT02325271

Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers

Intra-individual Variability and Circadian Rhythm of Systemic Vascular Endothelial Growth Factor (VEGF) Levels and Interaction With Biomarkers of Inflammation in Subjects With Normal Glucose Tolerance (NGT) and Patients With Type 2 Diabetes Without Diabetic Macular Edema (DME)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: GWT-TUD GmbH · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The study evaluates the intra-individual variability of VEGF levels over a period of 6 months as well as the circadian variation of VEGF levels, both under standardized conditions in patients with type 2 diabetes without DME and matched subjects with normal glucose tolerance (NGT). Secondary objectives of the study are to evaluate the relationship of individual VEGF-levels to biomarkers of inflammation, HbA1c and major cardiovascular risk factors.

Conditions

• Diabetic Macular Edema

Interventions

Type	Name	Description
OTHER	Frequent blood and urine sampling and blood pressure measurement	Blood and urine sampling for the determination of VEGF and biomarkers

Timeline

• Start date: 2015-02-01
• Primary completion: 2015-10-01
• Completion: 2016-01-01
• First posted: 2014-12-24
• Last updated: 2017-09-06

Locations

1 site across 1 country: Germany