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Active Not RecruitingNCT02323867

Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies

UNRELATED AND PARTIALLY MATCHED RELATED DONOR PERIPHERAL STEM CELL TRANSPLANTATION WITH Alpha/Beta T CELL AND B CELL DEPLETION FOR PATIENTS WITH HEMATOLOGIC MALIGNANCIES

Status
Active Not Recruiting
Phase
Phase 2
Study type
Interventional
Enrollment
140 (estimated)
Sponsor
Children's Hospital of Philadelphia · Academic / Other
Sex
All
Age
23 Years
Healthy volunteers
Not accepted

Summary

This is a single arm pilot study for patients using α/β T cell-depleted peripheral Stem Cell Transplantation (PSCT) in with alternative donor sources with hematologic malignancies receiving alternative donor (unrelated or partially matched related) mobilized peripheral stem cells (PSCs) using the CliniMACS system for T cell depletion plus CD19+ B cell depletion to determine efficacy as determined by engraftment and graft versus host disease (GVHD), and one year leukemia free survival.

Conditions

Interventions

TypeNameDescription
DEVICEAlpha Beta T cell depletion

Timeline

Start date
2014-10-01
Primary completion
2026-10-01
Completion
2027-10-01
First posted
2014-12-24
Last updated
2025-10-31

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT02323867. Inclusion in this directory is not an endorsement.

Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies (NCT02323867) · Clinical Trials Directory