NCT02318147

Fecal Microbiota Transplantation for Pancreatitis With Infectious Complications(FMTPIC)

Fecal Microbiota Transplantation in SAP（Severe Acute Pancreatitis）Patients With Infectious Complications

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: The First Affiliated Hospital of Nanchang University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Infectious complications are responsible for most of deaths in acute pancreatitis.Intestinal barrier dysfunction and increased intestinal permeability was associated with bacterial translocation which is believed to prompted these infections.The purpose of this clinical trail is to observe the potential capability of FMT in reduce the bacterial translocation and alleviate infectious complications by the reconstruction of a gut functional state.

Detailed description

Investigators aims to restore the intestinal bacteria homeostasis through FMT by retention enema with fresh bacteria,thus minimizing bacterial translocation and alleviating infectious complications. The investigators will further examine the effect of FMT on the incidence of infectious complications，duration of clinical course and mortality.

Conditions

• Acute Pancreatitis
• Fecal Microbiota Transplantation
• Bacterial Translocation
• Infectious Complications

Interventions

Type	Name	Description
PROCEDURE	Fecal Microbiota Transplantation	FMT by retention enema with fresh bacteria from healthy donor
DRUG	The traditional treatment	the traditional treatments according to associated guidelines

Timeline

• Start date: 2016-11-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2014-12-17
• Last updated: 2017-10-18

Locations

1 site across 1 country: China