NCT02311608

Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails

Comparative Effectiveness Research: Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails to Treat the Patients With Acute Variceal Bleeding

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,320 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

To observe and access the Effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients with acute variceal bleeding.

Detailed description

The prognosis information of the patients with acute variceal bleeding will be collected, including hemostasis rate, early rebleeding rate, mortality, complications, severity adverse events, economic burdens and quality of life, when terlipressin or high dose somatostatin/octreotide is used as salvation to patients fail to achieve initial hemostasis.The results may help gastroenterologists to make decisions when administering vasoactive medicines to those suffered from acute variceal bleeding.

Conditions

• Liver Cirrhosis
• Esophageal and Gastric Varices
• Hemorrhage

Interventions

Type	Name	Description
DRUG	Terlipressin	administered as a first-line medicine or as salvage
DRUG	Usual Dose Somatostatin/Octreotide	administered as a first-line medicine or as salvage
DRUG	High Dose Somatostatin/Octreotide	administered as salvage

Timeline

• Start date: 2014-02-01
• Primary completion: 2016-02-01
• Completion: 2016-06-01
• First posted: 2014-12-08
• Last updated: 2014-12-08

Locations

1 site across 1 country: China