NCT02310594

Anti-tumor Immune Response in Patients With Cancer Undergoing Radiation Therapy

The Effect of Radiation Therapy on Tumor Immunity

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 139 (actual)
• Sponsor: Jonsson Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This research trial studies the effect of radiation therapy on tumor immunity. Standard radiation therapy destroys tumor cells. In response to tumor cell death caused by radiation therapy, the body has an ability to stimulate an anti-tumor response (immunity), but this response is often ineffective in shrinking tumor tissue. Collecting samples of blood from patients before, during, and after radiation therapy to study in the laboratory may help doctors learn more about the effects of radiation therapy on anti-tumor response.

Detailed description

PRIMARY OBJECTIVES: I. To assess the effect of radiation therapy on tumor immunity. OUTLINE: Samples of blood are collected before, during, and within two weeks after radiation therapy and then stored for analysis of anti-tumor immunity.

Conditions

• Malignant Neoplasm

Interventions

Type	Name	Description
OTHER	cytology specimen collection procedure	Undergo blood sample collection
OTHER	laboratory biomarker analysis	Correlative studies

Timeline

• Start date: 2010-07-08
• Primary completion: 2022-08-09
• Completion: 2022-08-09
• First posted: 2014-12-08
• Last updated: 2022-08-18

Locations

1 site across 1 country: United States