NCT02310542

Comparison of Two Liver Dialysis Systems : MARS Versus SPAD in Severe Liver Failure

Comparison of Two Extracorporeal Liver Support System (With or Without Recirculation) : MARS (Molecular Adsorbents Recirculating System) Versus SPAD (Single Pass Albumin Dialysis) in Severe Liver Failure.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A critical issue of the clinical syndrome in liver failure is the accumulation of toxins not cleared by the failing liver. Based on this hypothesis, albumin dialysis is used to remove those substances. Albumin dialysis with recirculation (MARS) is the most used system but required specific system and expert environment. Alternative system without recirculation (SPAD) is less expensive and can be realised in critical care services trained to extrarenal epuration. The primary objective of this study is to compare biological and clinical efficacy, pulsatility index of middle cerebral artery modification and tolerance of both systems. This is a prospective, open, cross-over comparative study of two albumin dialysis system. Each patient will receive the two systems in an randomly assessed order. Patients are divided up according to bilirubin plasmatic level. (250µmol/L to 400 µmol/L and \>400µmol/L).

Conditions

• Liver Failure, Acute
• Chronic Hepatic Failure

Interventions

Type	Name	Description
DEVICE	MARS albumin dialysis system
DEVICE	SPAD albumin dialysis system

Timeline

• Start date: 2011-12-01
• Primary completion: 2017-09-30
• Completion: 2017-09-30
• First posted: 2014-12-08
• Last updated: 2025-09-11

Locations

1 site across 1 country: France