NCT02310373

Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

• Status: Terminated
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Cedars-Sinai Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

This is a pilot study on the acute effects of nicotine-free hookah (herbal/steam stones) smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. The contribution of nicotine to these effects is unknown. Here the investigators will directly measure the acute effects of nicotine-free Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.

Conditions

• Nicotine-free Hookah Smoking

Interventions

Type	Name	Description
OTHER	Nicotine free hookah smoking	Subjects will smoke waterpipe in a controlled research environment

Timeline

• Start date: 2014-11-01
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2014-12-08
• Last updated: 2020-01-13

Locations

1 site across 1 country: United States