NCT02305940

Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients

A Phase III Double-blind, Randomised, Placebo Controlled Trial of Long Term Therapy on Exacerbation Rate in Patients With Stable COPD Using Doxycycline

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 222 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

This study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in COPD patients. Half of the patients will receive doxycycline which the other half will receive a placebo.

Detailed description

Chronic Obstructive Pulmonary Disease (COPD) is a common disease which can place a considerable burden on people who suffer from it. COPD exacerbations (periods when symptoms flare up) are a major cause of hospital admission in the UK. Bacterial infections play an important role in the development of COPD and so one possible treatment for COPD is with antibiotics. However, there is little information available about the use of long term antibiotics in the treatment of this disease. Therefore, the purpose of this study is to investigate if long term use of the antibiotic Doxycycline can reduce exacerbations and improve the outlook for these patients.

Conditions

• Chronic Obstructive Pulmonary Disease (COPD)

Interventions

Type	Name	Description
DRUG	Doxycycline	An oral dose of 100 mg of Doxycycline once daily, for a total duration of 52 weeks.
DRUG	Placebo	An oral dose of one capsule of placebo once daily, for a total duration of 52 weeks

Timeline

• Start date: 2014-07-01
• Primary completion: 2017-07-12
• Completion: 2017-07-12
• First posted: 2014-12-03
• Last updated: 2017-07-26

Locations

3 sites across 1 country: United Kingdom