NCT02303080

Whey Protein Micelles and Thermogenesis in Overweight Subjects

Whey Protein Micelles and Thermogenesis In Overweight Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Société des Produits Nestlé (SPN) · Industry
• Sex: All
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The main objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels. It will be a randomized crossover double-blind design conducted in 20 subjects.

Detailed description

Primary objective and outcome: The primary objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels (WPM). Secondary objectives and outcomes: Explore the mechanism of action of WPM on thermogenesis including: Protein turnover in response to the dose and the source of protein (WPM versus casein) Insulinemic and glycemic response to the dose and source of protein (WPM versus casein) Design: The proposed study is a randomized double-blind, placebo-controlled, single center, crossover design. At the start of the study, subjects will be randomly assigned to 4 different groups in a crossover design, where they will be asked to consume a beverage containing Product 1: 0g of protein (maltodextrin control) Product 2: 30g of WPM Product 3: 50g of WPM Product 4: 50g of micellar casein (MC) Number of subjects: The number of subjects will be 15. Sufficient subjects should be recruited to provide a 30% drop-out rate. Therefore 20 subjects will be needed including drop-outs.

Conditions

• Overweight

Interventions

Type	Name	Description
OTHER	Control (WPM 0)	85.0 % maltodextrin,15.0% fat, 0% WPM
OTHER	WPM 30	43.7% maltodextrin, 15.2% fat, 41.1% (30 g) WPM
OTHER	WPM 50	16.3% maltodextrin, 15.2% fat, 68.5% (50 g) WPM
OTHER	MC 50	16.7% maltodextrin, 15.0% fat, 68.2% (50 g) MC

Timeline

• Start date: 2010-11-01
• Primary completion: 2012-06-01
• Completion: 2012-12-01
• First posted: 2014-11-27
• Last updated: 2025-05-14