NCT02300012

A Pilot Study to Investigate Biomarkers in Anterior Cruciate Ligament (ACL) Patients and Healthy Controls

A Pilot Study to Investigate Biomarkers in ACL Patients and Healthy Controls

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: United Lincolnshire Hospitals NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Incident rates of ACL rupture are greatest in 16-39 year olds at almost 1 in 1,000. Performance Based Investigations (PBIs) can be used to evaluate and select correct approaches to patient treatment, and biochemical, biomechanical and physiological biomarkers in other conditions are sensitive in distinguishing between disease state severities, type of injuries and responsiveness to treatment. Despite the measurement sensitivity of PBIs, these are not widely used possibly owing to their focus postoperatively where benefits are less worthwhile. This study aims to investigate novel biomarkers as performance based investigations (PBIs) to improve surgical and treatment strategies in anterior cruciate ligament (ACL) patients. The objectives are to identify whether biomarkers, collected before and after operations, can: 1) Assist the surgeon in decision making; 2) Lead to improved prognosis; 3) Be used to predict the outcomes of prognosis, and; 4) Correlate with disease signs/ smoking to help further understand ACL injuries.

Conditions

• Rupture of Anterior Cruciate Ligament

Interventions

Type	Name	Description
PROCEDURE	Surgeons knowledge of pre-operative PBIs	Surgeon performing ACL repair will have prior knowledge of patients pre-operative PBIs to inform surgical practice

Timeline

• Start date: 2015-01-05
• Primary completion: 2022-05-20
• Completion: 2022-05-20
• First posted: 2014-11-24
• Last updated: 2022-05-27

Locations

1 site across 1 country: United Kingdom