NCT02296658

A Phase II Study of Postoperative S-1-Based Chemoradiotherapy in Gastric Cancer

A Phase II Trial of Intensity-Modulated Radiotherapy Combined With S-1 Based Chemotherapy in Completely Resected Gastric Cancer

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Chinese Academy of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this phase II trial was to evaluate the feasibility, efficacy and tolerability of intensity-modulated radiotherapy combined with S-1 based chemotherapy in patients with pathologically positive lymph node after completely resected gastric cancer. Furthermore, the investigators sought to compare the dosimetric differences between the volumetric-modulated arc therapy (VMAT), Tomotherapy and intensity-modulated radiotherapy (IMRT) techniques in treatment planning for gastric cancer as adjuvant radiotherapy.

Conditions

• Stomach Neoplasms
• Chemoradiotherapy, Adjuvant
• Radiotherapy, Intensity-Modulated

Interventions

Type	Name	Description
RADIATION	intensity-modulated radiotherapy	A total irradiation dose of 45 Gy was delivered in daily 1.8-Gy fractions (5 days a week over 5 weeks) to all patients.
DRUG	S-1	S-1,80mg/m2/d,peroral BID,in treatment days concurrently with intensity-modulated radiotherapy.

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-12-01
• Completion: 2016-12-01
• First posted: 2014-11-20
• Last updated: 2014-11-20

Locations

1 site across 1 country: China