NCT02295553

Ketamine and Propofol for Upper Endoscopy

Co-administration of Ketamine and Propofol for Upper Endoscopy in Children: a Dose-finding Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 3 Years – 13 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the dose-response relationship of ketamine in combination with propofol.

Detailed description

Direct visualization of the esophagus, stomach and small intestine is performed using a scope that is inserted while the patient is under under deep sedation or general anesthesia. The most common method of providing general anesthesia for upper endoscopy is intravenous administration of medications such as propofol, often in combination with other medications such as fentanyl, midazolam, remifentanil or ketamine. One study found that the combination of propofol and ketamine provides better conditions (less patient movement, more stable heart and breathing) but more side effects afterwards compared to propofol and fentanyl.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Ketamine
DRUG	Propofol

Timeline

• Start date: 2013-07-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2014-11-20
• Last updated: 2019-06-10
• Results posted: 2019-06-10

Locations

1 site across 1 country: Canada