NCT02294032

The Role of B Cells in Kidney Allograft Dysfunction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 180 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 2 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to understand the role of specific B cells in activating or repressing an anti-allograft immune response after kidney transplantation. In this study, blood will be collected from kidney transplant patients during different timepoints, prior to and after their transplant. Knowledge gained from study findings will be used to develop therapeutic strategies to prevent antibody-mediated rejection, which is a major cause of long-term graft loss in kidney transplant patients.

Detailed description

The purpose of this study is to understand the role of specific B cells in activating or repressing an anti-allograft immune responses after kidney transplantation. This study aims to address two major challenges in kidney transplantation: 1. to guide physicians when immunosuppressive drugs are weaned, and 2. to identify patients who are at risk or in the process of developing antibody-mediated rejection. In this study, blood will be collected from kidney transplant patients during different timepoints, prior to and after their transplant. Knowledge gained from study findings will be used to develop therapeutic strategies to prevent antibody-mediated rejection, which is a major cause of long-term graft loss in kidney transplant patients.

Conditions

• Kidney; Complications, Allograft
• Transplantation Infection

Interventions

Type	Name	Description
DRUG	Immunosuppressive Agents	standard of care for patients post-transplant

Timeline

• Start date: 2014-08-28
• Primary completion: 2023-04-24
• Completion: 2023-04-24
• First posted: 2014-11-19
• Last updated: 2023-05-19

Locations

1 site across 1 country: United States