NCT02292342

An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men

An Acute, Double-blind, Randomised, Placebo-controlled, Crossover Intervention Trial Investigating the Dose-dependent Vascular Effects of Pure (-)-Epicatechin (≤1 mg/kg BW) in Healthy Men.

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Reading · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Aim: To investigate the dose-dependent vascular effect (primarily using FMD) of 3 low-level doses of pure (-)-epicatechin ≤ 1 mg/kg BW (0.1, 0.5 \& 1.0 mg/kg BW) in healthy men.

Conditions

• Vasodilation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Water	Control
DIETARY_SUPPLEMENT	Epicatechin 0.1 mg/kg	EC 0.1 mg/kg
DIETARY_SUPPLEMENT	Epicatechin 0.5 mg/kg	EC 0.5
DIETARY_SUPPLEMENT	Epicatechin 1.0 mg/kg	EC 1.0

Timeline

• Start date: 2014-05-01
• Primary completion: 2016-02-01
• Completion: 2016-05-01
• First posted: 2014-11-17
• Last updated: 2016-05-30

Locations

1 site across 1 country: United Kingdom