NCT02291302

School Inner-City Asthma Intervention Study (SICAS-2)

School Inner-City Asthma Intervention Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 236 (actual)
• Sponsor: Boston Children's Hospital · Academic / Other
• Sex: All
• Age: 4 Years – 15 Years
• Healthy volunteers: Accepted

Summary

The investigators goal is to determine the efficacy of school/classroom based environmental intervention in reducing asthma morbidity in urban schoolchildren.

Detailed description

Our proposal builds upon our established, successful school-based infrastructure to determine whether a school/classroom intervention will efficiently and effectively improve asthma morbidity by reducing these exposures. Our goal is to determine the efficacy of school/classroom based environmental intervention in reducing asthma morbidity in urban schoolchildren. Our central hypothesis is that reducing classroom/school exposure to mouse allergen, mold, and particulate pollutants will decrease asthma morbidity in students with asthma. The investigators plan to test this hypothesis in an intervention study of 300 elementary students with asthma from multiple classrooms in inner-city elementary schools. Our clinical trial aims are to determine the effectiveness of a school/classroom based environmental intervention (school integrated pest management and classroom air purifying filter units within these schools) to reduce asthma morbidity. Our mechanistic aim is to test the hypothesis that effects of school/classroom-based environmental interventions on symptoms/other measures of asthma control occur through changes in gene methylation or expression in pathways (and secondarily, in genes) relevant to airway function and asthma. This will expand our understanding of asthma immunopathogenesis and create opportunities to identify potential novel targets for asthma therapy.

Conditions

• Asthma

Interventions

Type	Name	Description
OTHER	integrated pest management	integrated pest management and environmental strategy
OTHER	air purifier	air purifiers
OTHER	No intervention (control)	no integrated pest management and sham air purifier

Timeline

• Start date: 2015-01-01
• Primary completion: 2020-06-01
• Completion: 2020-06-01
• First posted: 2014-11-14
• Last updated: 2025-01-07
• Results posted: 2020-09-23

Locations

1 site across 1 country: United States