NCT02290834

Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: Female
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.

Detailed description

* This study is being done to study effects of chemotherapy (cancer treatment) on the brain and cognition (thinking). "Chemo-brain" is a term sometimes used to refer to effects of chemotherapy on the brain and cognition (thinking). * This study is being done to test for "chemo-brain" in older adults with breast cancer treated with chemotherapy, and to identify people who are most likely to be affected. The investigators will look at thinking abilities and brain images before and after chemotherapy to see if it can help identify people at risk for cognitive side effects of the treatment, and to better understand effects of treatment on brain structure and function. * The investigators are looking for participants who have either been recently recently diagnosed breast cancer participant or a healthy volunteer. * What is involved in the study: * Memory and Thinking Tests * Imaging: Either MRI/or MRI and PET Scans

Conditions

• Impaired Cognition
• Chemo-brain
• Breast Cancer

Interventions

Type	Name	Description
OTHER	Cognitive, functional and subjective assessments	Cognitive and functional assessments
DEVICE	MRI	Magnetic Resonance Imaging (MRI) Scan
RADIATION	PET Scan	Positron Emission Tomography (PET) Scan

Timeline

• Start date: 2015-03-01
• Primary completion: 2028-01-01
• Completion: 2028-01-01
• First posted: 2014-11-14
• Last updated: 2026-03-11

Locations

2 sites across 1 country: United States