NCT02288819

Spot Urinary Analysis to Assess Loop Diuretic Efficiency in Stable Heart Failure

Diuretic Efficiency in Patients With Stable Heart Failure: Ion Excretion Capacity of the Kidneys (DIPSTICK) Study

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Hasselt University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to assess whether the urinary sodium/creatinine or chloride/creatinine ratio might predict successful downtitration of loop diuretics in patients with stable heart failure without clinical signs of volume overload. In addition, this study will provide information on loop diuretic efficiency and urinary electrolyte composition after intake of diuretics in stable outpatients with heart failure.

Conditions

• Heart Failure

Interventions

Type	Name	Description
DEVICE	Weight monitoring	The body weight of patients is measured each morning in identical conditions on the same balance during 7 days
DRUG	Loop diuretic downtitration	The patient's total daily maintenance dose of loop diuretics is downtitrated during 7 consecutive days. In case of a total daily maintenance dose ≤40 mg furosemide OR ≤1 mg bumetanide OR ≤20 mg torsemide, the loop diuretic is completely stopped. In case of a total daily maintenance dose \>40 mg furosemide OR \>1 mg bumetanide OR \>20 mg torsemide, the loop diuretic dose is halved.

Timeline

• Start date: 2014-09-01
• Primary completion: 2016-03-01
• Completion: 2016-04-01
• First posted: 2014-11-11
• Last updated: 2019-04-16
• Results posted: 2019-04-16

Locations

1 site across 1 country: Belgium