NCT02288143

COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation

Evaluation of a Simplified Low-cost and Friendly Controlled Ovarian Stimulation Combining Oral Letrozole and Clomiphene Citrate: a Pilot Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot study evaluating the effect of a simplified low-cost (friendly) controlled ovarian stimulation using clomiphene citrate, letrozole, and low-dose hMG on the number of oocytes retrieved.

Conditions

• Infertility

Interventions

Type	Name	Description
DRUG	COOL-COS	Controlled ovarian stimulation will start on the second or third day of a menstrual cycle: * Oral clomiphene citrate: 100 mg/day until the day of the triggering. * Oral letrozole: 7.5 mg/day during the first 5 days of the controlled ovarian stimulation. * hMG: 150 IU every other day beginning on the day 6 of the controlled ovarian stimulation. The triggering will be performed using urinary hCG (5,000 IU subcutaneous). * 1-2 days after the identification of one follicle ≥ 17 mm * 0-1 days after the identification of one follicle ≥ 19 mm.

Timeline

• Start date: 2015-01-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2014-11-11
• Last updated: 2015-12-02

Locations

1 site across 1 country: Brazil