NCT02287545

Biomechanical Changes After Trabeculectomy

Corneal Biomechanical Changes Following Trabeculectomy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Technische Universität Dresden · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Corneal biomechanics are studied in glaucoma patients prior and at least 6 month after trabeculectomy.

Detailed description

Prior to trabeculectomy corneal biomechanics are measured with the Ocular Response Analyzer (ORA, Reichert) and the Corvis st (Oculus). Both instruments work with an air-puff which deforms the cornea. Intraocular pressure is measured like in non-contact air-puff tonometry. The ORA also measures corneal hysteresis (CH) and the corneal resistance factor (CRF) which are qualitative measures of corneal biomechanics. The Corvis is a high-speed Scheimpflug-camera (4330 frames/sec) that records the quantitative movements of the cornea. At least 6 month after uncomplicated trabeculectomy the measurements are repeated.

Conditions

• Glaucoma, Primary

Interventions

Type	Name	Description
PROCEDURE	trabeculectomy	Standard trabeculectomy with the use of antimetabolites (mitomycin C) for glaucoma patients with insufficient intraocular pressure (IOP) control taking maximally tolerated IOP-reducing medication, visual field progression despite maximally tolerated IOP-reducing medication, adverse events because of maximally tolerated IOP-reducing medication or nono.compliance.

Timeline

• Start date: 2013-02-01
• Primary completion: 2015-02-01
• Completion: 2015-02-01
• First posted: 2014-11-10
• Last updated: 2015-08-21

Locations

1 site across 1 country: Germany