NCT02286596

Comparisons of Two Low-density Lipoprotein Apheresis Systems in Patients With Homozygous Familial Hypercholesterolemia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Homozygous familial hypercholesterolemia (HoFH) is characterized by a six- to eight-fold raise in plasma LDL-cholesterol (LDL-C) concentrations and atherosclerotic coronary artery disease usually occur before the age of 20 if untreated. Lipid apheresis (LA) has been proved to be a reliable method to decrease LDL-C concentrations and therefore decrease cardiovascular disease risk in HoFH. The objective of this crossover study was to compare efficacy of LA performed with heparin-induced extracorporeal LDL precipitation to dextran sulfate adsorption on the reduction of lipids, inflammatory markers, adhesion molecules and LDL particles size in a cohort of HoFH subjects.

Conditions

• Homozygous Familial Hypercholesterolemia

Interventions

Type	Name	Description
DEVICE	heparin-induced extracorporeal LDL precipitation	Lipid apheresis for 3 hours
DEVICE	dextran sulfate adsorption	Lipid apheresis for 3 hours

Timeline

• Start date: 2013-04-01
• Primary completion: 2013-06-01
• Completion: 2014-12-01
• First posted: 2014-11-10
• Last updated: 2016-03-08

Locations

1 site across 1 country: Canada