NCT02286505

Automated Brain Morphometry for Dementia Diagnosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 51 Years
• Healthy volunteers: Not accepted

Summary

Early dementia diagnosis improves patient and carer experience, links them to appropriate care and support and enables timely symptomatic treatment. The guidelines of the UK National Institute for Health and Care Excellence recommend brain Magnetic resonance imaging (MRI) to assist with the diagnosis in suspected dementia. Recently, computerised analysis of MRI scans, also known as automated brain morphometry, has shown potential to detect the brain changes characteristic of early dementia, and may therefore be a useful addition to the standard reporting performed by a neuroradiologist. The present pilot study will assess whether adding brain morphometric analysis to the usual diagnostic pathway improve diagnosis in clinical practice as an addition to the existing diagnostic pathway in a memory clinic setting. The main purpose of the study is to compare measures of the clinicians diagnostic confidence in patients with and without brain morphometry.

Conditions

• Dementia

Interventions

Type	Name	Description
DEVICE	Brain Morphometry	Quantitative, automated reading of hippocampal volume from MRI scans, complemented by a general measure of brain atrophy, in addition to standard neuroradiological report.
OTHER	Standard radiological assessment	Standard neuroradiological report produced by qualitative examination of structural MRI scan by trained neuroradiologist.

Timeline

• Start date: 2014-11-01
• Primary completion: 2016-03-01
• Completion: 2016-03-01
• First posted: 2014-11-07
• Last updated: 2014-11-07

Locations

1 site across 1 country: United Kingdom