NCT02286336

The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: Huazhong University of Science and Technology · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine the minimum effective concentration of local anesthetic (ropivacaine 40mL) required to produce an effective double-injection USG-SCB for surgical anesthesia in 90% of patients (MEC90) in young group (18-40 years) and in middle aged group (40-65 years) of patients scheduled for elective surgery of one upper limb distal to the shoulder.

Detailed description

The study is based on biased coin design, and the concentration of LA for the next patient is determined by the result of the last one. In the case of block failure, the concentration will be increased by 0.025%. Conversely, block success will result in either a reduction in concentration by 0.025% (probability 11%) or no change in concentration (probability 89%). A blinded assistant will assess sensory and motor blockade in each nerve territory ( the median, radial, ulnar and musculocutaneous nerves) at 10-min intervals up to 30 min after completion of the block. Finally, MEC90 is calculated by isotonic regression.

Conditions

• Minimum Effective Concentration of Local Anesthetic

Interventions

Type	Name	Description
OTHER	brachial plexus block	brachial plexus block with ropivacaine 40ml

Timeline

• Start date: 2014-10-01
• Primary completion: 2015-02-01
• Completion: 2015-03-01
• First posted: 2014-11-07
• Last updated: 2015-07-28

Locations

1 site across 1 country: China