NCT02278211

Prediction of Recurrent Events With 18F-Fluoride

Prediction of Recurrent Events With 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients With Myocardial Infarction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 995 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

This is a multi-centre observational study. It will make use of the positron emission tomography (PET) tracer 18F-sodium fluoride (18F-NaF) as a marker of coronary plaque vulnerability to detect culprit and non-culprit unstable coronary plaques in patients with recent myocardial infarctions. The investigators will then perform long-term follow-up of these patients to determine the prognostic significance of coronary 18F-NaF uptake

Detailed description

The investigators intend to recruit 700 patients hospitalised with myocardial infarction and proven multivessel coronary artery disease. All patients will undergo a combined CT coronary angiogram (CTCA) and PET scan using 18F-NaF as a tracer. Patients will then have clinical follow-up before undergoing a repeat CTCA at 2 years to assess progression of coronary disease. Clinical review of all patients will continue until study completion (given 2 years of recruitment this is likely to last 4 years) and following this the investigators will continue to monitor for further cardiovascular events via review of patient electronic health records for a further 5 years.

Conditions

• Coronary Artery Disease
• Myocardial Infarction

Timeline

• Start date: 2015-10-01
• Primary completion: 2022-03-01
• Completion: 2022-05-01
• First posted: 2014-10-29
• Last updated: 2025-03-17
• Results posted: 2025-03-17

Locations

1 site across 1 country: United Kingdom