NCT02275702

Randomized Study of Preoperative Dexamethasone for Quality of Recovery in VATS Lung Resection Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The proposed study is a randomized, double-blind, placebo-controlled evaluation if a small dose of IV dexamethasone during induction anesthesia in association to pre and postoperative intercostal nerve block, improves quality of recovery of thoracoscopic lung resection patients.

Detailed description

This is a study composed by 2 groups of 50 patients undergoing VATS for lung cancer. All subjets will receive intraoperative intercostal nerve block with a maximum dose of 2 mg/kg of bupivacaine with epinephrine 1:200.000 at the beginning and at the end of procedure. The control group will receive a bolus dose of dexamethasone (0.1 mg/kg) and the placebo group saline solution. The study drug or placebo will be administered at the time of anesthetic induction (approximately 30 minutes before surgical incision). Patients will be evaluated daily with the quality of recovery questionary, visual analogue pain and portable spirometry. And, the patients will have pulmonary lung function assessed by portable spirometry.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
DRUG	Dexamethasone IV	It will be administered at the induction of the anesthesia
DRUG	Saline solution

Timeline

• Start date: 2014-10-01
• Primary completion: 2016-10-01
• Completion: 2016-12-01
• First posted: 2014-10-27
• Last updated: 2021-08-25

Locations

2 sites across 1 country: Canada