NCT02272985

Cerebral Blood Flow During Hemodialysis

A [15O]H2O PET-CT Pilot Study Comparing Cerebral Blood Flow Before, During and After Hemodialysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effect of the hemodialysis procedure on cerebral blood flow (CBF) in elderly maintenance hemodialysis (HD) patients. The investigators hypothesize that HD induced blood pressure changes are associated with a fall in global and/or regional CBF during HD. Second, the investigators hypothesize that near infrared spectroscopy (NIRS) will correlate with CBF measured by\[15O\]H2O PET.

Detailed description

The investigators aim to include 14 participants. Each participant will undergo a single HD study session in the PET center of the UMCG. During this study session, each participant will undergo three gated \[15O\]H2O PET-CT scans before, during (after 20 minutes) and at the end of the HD session. NIRS will be used to measure cerebral tissue regional oxygen saturation (rSO2) during the HD study session. INVOS (In Vivo Optical Spectroscopy), a monitoring device, will be used to measure rSO2, with sensors placed bilaterally on the patient forehead. Participants will further undergo a MRI scan of the brain, bilateral carotid artery duplex echosonography, cognitive testing, blood pressure and heart rate measurements during the HD study session, and laboratory measurements during the HD study session.

Conditions

• Haemodialysis-induced Symptom

Interventions

Type	Name	Description
OTHER	[15O]H2O PET-CT scan	All participants will undergo 3 \[15O\]H2O PET-CT scans during the hemodialysis study session
OTHER	NIRS (Invos)	All participants will undergo near infrared spectroscopy (NIRS) during the hemodialysis study session.

Timeline

• Start date: 2015-04-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2014-10-23
• Last updated: 2020-04-07
• Results posted: 2019-01-16

Locations

1 site across 1 country: Netherlands