NCT02272556

Investigating the Role of the Polyol Pathway in the Central Nervous System

Investigating the Role of Polyol Pathway in the Central Nervous System

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 138 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.

Conditions

• Hyperglycemia

Interventions

Type	Name	Description
OTHER	Brain MRS during hyperglycemic clamp	All patients will undergo brain MRS at baseline and following 2 and 4 hours of hyperglycemia using the clamp technique
OTHER	Analysis of Metabolites in cerebrospinal fluid	All patients will have the option to undergo a lumbar puncture for analysis of metabolites in cerebrospinal fluid

Timeline

• Start date: 2015-02-01
• Primary completion: 2022-05-18
• Completion: 2022-05-18
• First posted: 2014-10-23
• Last updated: 2022-08-18

Locations

1 site across 1 country: United States