Trials / Completed
CompletedNCT02272270
Phase I Newly Diagnosed GBM With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide (D-TERMINED)
Phase 1 Trial in Newly Diagnosed High Grade Glioma With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide. (D-TERMINED)
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 25 (actual)
- Sponsor
- University of Utah · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This will be an open label, single arm study. Subjects with newly diagnosed high grade glioma will begin minocycline one week prior to beginning postoperative chemoradiation and continue it until progression, intolerance, or the end of adjuvant temozolomide, whichever comes first.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Minocycline with chemoradiation (temozolomide and radiation therapy) | Patients receive minocycline in conjunction with standard chemoradiation and then they receive minocycline with standard chemotherapy. |
Timeline
- Start date
- 2014-10-27
- Primary completion
- 2017-03-08
- Completion
- 2018-02-18
- First posted
- 2014-10-22
- Last updated
- 2019-06-19
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02272270. Inclusion in this directory is not an endorsement.