NCT02272049

Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Use of Hyperpolarized 129 Xe MR Lung Imaging in Children and Adults

• Status: Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Children's Hospital Medical Center, Cincinnati · Academic / Other
• Sex: All
• Age: 6 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Detailed description

Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a single day and will involve administration of (maximum) 1 liter doses (less for children) for up to four MRI scans. Subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds during the MRI scans. In addition to 129 Xe MRI, a series of anatomical conventional proton MR images may also be collected. Follow up phone calls will be done one day and 30 days from the MRI date.

Conditions

• Respiratory Disorders

Interventions

Type	Name	Description
DRUG	Hyperpolarized 129 Xenon	During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans

Timeline

• Start date: 2014-12-01
• Primary completion: 2028-12-31
• Completion: 2029-08-31
• First posted: 2014-10-22
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States