NCT02271633

Nitrate Supplementation; Source

The Effect of Nitrate Supplementation: Source of Supplementation

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The main aim of the current study will be to compare the effects of ingesting different nitrate-rich sources on plasma nitrite concentrations.

Detailed description

Oral ingestion of nitrate (NO3-) has been shown to increase plasma nitrate and nitrite levels. Significant lowering of pulmonary oxygen uptake during exercise, as well as significantly lower blood pressure values at rest have been observed after supplementation with nitrate. However, no study has yet described a direct comparison between different nitrate-rich beverages with respect to the bioavailability of nitrate/nitrite and the possible hemodynamic effects. Based on the gaps in current literature, our main goal will therefore be to gain further insight into the effects of nitrate supplementation with different sources on plasma nitrite levels.

Conditions

• Blood Pressure
• Nutritional Physiological Phenomena

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Sodium nitrate
DIETARY_SUPPLEMENT	Beetroot juice
DIETARY_SUPPLEMENT	Spinach
DIETARY_SUPPLEMENT	Rocket salad

Timeline

• Start date: 2014-09-01
• Primary completion: 2014-12-01
• Completion: 2016-03-01
• First posted: 2014-10-22
• Last updated: 2016-03-16

Locations

1 site across 1 country: Netherlands