NCT02271555

The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy

Inonu University, Turgut Ozal Medical Center, Department of Anesthesiology and Reanimation Malatya

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 58 (estimated)
• Sponsor: Inonu University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators will be evaluated the effects of a single loading dose of remifentanil (1µg/kg), administered as an adjunct to sevoflurane, on duration of hemodynamic profile, seizure activity, and recovery times during electroconvulsive therapy (ECT) in patients with major depression

Detailed description

Major depressive patients will enrolled this trial. Mean arterial pressure (MAP) and heart rate (HR) and peripheral oxygen saturation values will be recorded prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 minute after the seizure have ended (T3, T4, T5, and T6, respectively). The peak heart rate during the seizure will be recorded from the Electrocardiogram.

Conditions

• Haemodynamic Rebound

Interventions

Type	Name	Description
DRUG	Sevoflurane	Anesthetic induction will be achieved via 8% sevoflurane
DRUG	Remifentanil	After the loss of consciousness remifentanil will be administered to Group sevoflurane-remifentanil in the form of a 1 µg/kg intravenous bolus.
DRUG	Saline	After the loss of consciousness saline will be administered to Group sevoflurane-saline intravenous bolus.

Timeline

• Start date: 2014-10-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2014-10-22
• Last updated: 2014-10-22

Locations

1 site across 1 country: Turkey (Türkiye)