NCT02269111

Quantitative MRI in Assessing Disease in Patients With Brain Tumors

Quantitative High-Field Magnetic Resonance Imaging (MRI) for Assessing Brain Metastases

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot clinical trial studies quantitative magnetic resonance imaging (MRI) at 3 Tesla in assessing disease in patients with tumors that have spread to the brain (brain metastases). In addition to routine care brain imaging of the brain, this study will include advanced multiparametric MRI sequences to measure vascular, cellular, and molecular properties of the tumor. Performing extra scans during MRI provides more information about the metastases and may better predict treatment response.

Detailed description

PRIMARY OBJECTIVES: I. To correlate pre-treatment measures of biophysical parameters in metastases-obtained using advanced, quantitative MRI techniques in patients receiving standard-of-care (SOC) therapy for 1-4 brain metastases-with treatment-induced changes in lesion size, time-to-progression (TTP), and overall survival (OS). OUTLINE: Patients undergo hybrid 3 Tesla MRI examination that includes standard MRI sequences, diffusion-weighted (DW)-MRI, chemical exchange saturation transfer (CEST), and combined dynamic contrast enhanced (DCE)-MRI/dynamic susceptibility contrast (DSC)-MRI at baseline.

Conditions

• Tumors Metastatic to Brain
• Unspecified Adult Solid Tumor, Protocol Specific

Interventions

Type	Name	Description
PROCEDURE	diffusion-weighted magnetic resonance imaging	Undergo DW-MRI
PROCEDURE	chemical exchange saturation transfer magnetic resonance imaging	Undergo CEST-MRI
PROCEDURE	dynamic contrast-enhanced magnetic resonance imaging	Undergo DCE-MRI
PROCEDURE	dynamic susceptibility contrast-enhanced magnetic resonance imaging	Undergo DSC-MRI

Timeline

• Start date: 2015-04-01
• Primary completion: 2017-10-01
• Completion: 2018-05-01
• First posted: 2014-10-20
• Last updated: 2018-05-29

Locations

1 site across 1 country: United States