NCT02267005

The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 7 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

This project will bring together a multidisciplinary team of pediatric rheumatologists, neurologists, metabolic geneticists and exercise physiologists to determine the effect of creatine (CR) supplementation on muscle function and muscle metabolism in children with Dermatomyositis (DM). The investigators propose using well-established exercise testing techniques as well as new, powerful exercise imaging protocols in order to better delineate the effects of CR on muscle pathophysiology in a non-invasive way. Evidence from this study will provide information regarding the effect of creatine supplementation on muscle function in DM. Improvements in muscle function and fatigue through CR use may also contribute to an improvement in quality of life and have significant clinical implications for the treatment of children with DM.

Conditions

• Juvenile Dermatomyositis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creapure	Patients will be prescribed a creapure supplement by weight, to be taken 3x/day for the duration of the trial. They will be randomized to an active product start time using a multiple baseline design.
DIETARY_SUPPLEMENT	Glucose Tablet	Patients will be prescribed the placebo supplement by weight, to be taken 3x/day for the duration of the trial. They will be randomized to an active product start time using a multiple baseline design.

Timeline

• Start date: 2015-03-01
• Primary completion: 2017-05-01
• Completion: 2017-05-01
• First posted: 2014-10-17
• Last updated: 2018-05-11

Locations

1 site across 1 country: Canada