NCT02265900

Parkinson's Disease Exercise TMS PET Study

Exercise and Parkinson's Disease: The Basis for Motor and Cognitive Benefits

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Pacific Parkinson's Research Centre · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The therapeutic effects of exercise in Parkinson's disease (PD) are commonly reported, however the mechanisms are unknown. The purpose of this study is to investigate the potential mechanisms of exercise in the brain for the treatment of PD.

Detailed description

Positron Emission Tomography will be used to measure dopamine neuron density, endogenous dopamine release and neuroimflammation. We will also use functional magnetic resonance imaging (fMRI) to measure brain activity. Assessments will be conducted before and after a 12-week exercise intervention and 3-year follow-up. Participants will be randomly allocated into either an aerobic or a stretching intervention. Clinical measures of motor function, cognition and mood will also be assessed.

Conditions

• Parkinson Disease

Interventions

Type	Name	Description
OTHER	Exercise	One type of exercise
OTHER	Exercise	A different type of exercise

Timeline

• Start date: 2014-11-01
• Primary completion: 2020-03-12
• Completion: 2020-03-12
• First posted: 2014-10-16
• Last updated: 2021-03-17

Locations

1 site across 1 country: Canada