NCT02265874

Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Ohio State University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if nicotine treatment is beneficial for the treatment of sarcoidosis. Sarcoidosis is a disease of unknown cause that leads to inflammation. This disease affects your body's organs.

Detailed description

Participants will be randomly divided into two groups. One group will receive a nicotine patch to use for approximately 7 months; the other group will receive placebo for nicotine patches to use for the same time period. Both groups will be contacted weekly by phone for the first 3 weeks then monthly for the duration of the study to monitor for any side effects. The following information and samples will be collected: Questionnaires Medical History Spirometry CT Scans Physical Exam Blood Samples for nicotine and nicotine metabolites

Conditions

• Sarcoidosis

Interventions

Type	Name	Description
DRUG	Habitrol	Patch used daily for 28 weeks
DRUG	Placebo to Habitrol

Timeline

• Start date: 2015-10-21
• Primary completion: 2021-11-01
• Completion: 2021-11-01
• First posted: 2014-10-16
• Last updated: 2025-04-24
• Results posted: 2025-04-24

Locations

1 site across 1 country: United States