NCT02265055

Early Embryo Cleavage And Multiple Pregnancies After ICSI

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 193 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: Female
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

To observe whether Number of early cleavage embryos can be a predictor for multiple pregnancies after ICSI.

Detailed description

A total of 193 infertile couples, attending the ART unit, International Islamic Center for Population Studies and Research (IICPSR), -Al- Azhar University in the period from December 2010 to September 2012, were included in this study. The controlled ovarian hyperstimulation protocol was performed according to a long GnRH agonist protocol starting in the midluteal phase (day 21) of the preceding cycle. Embryos were assessed at 25 - 27 hr after ICSI for early cleavage. Embryos which reached the two cell stage at this interval were classified as Early Cleavage (EC) embryos, and the remaining as Non Early Cleavage (NEC) embryos. Embryos were assessed again at 64 - 68 hours post-ICSI for day-three embryo morphology. Day 3 embryo transfer was done. The best two or three embryos, according to day 3 embryo morphology were transferred. The patients were subdivided into two subgroups; one will transfer early cleavage embryos (EC) and the other will transfer non early cleavage embryo (NEC).

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	transfer early cleavage embryos	transfer early cleavage embryos
PROCEDURE	transfer non early cleavage embryo

Timeline

• Start date: 2010-12-01
• Primary completion: 2012-09-01
• Completion: 2012-12-01
• First posted: 2014-10-15
• Last updated: 2014-10-15