NCT02264951

Fat-induced Release of GLP-1 in Humans

Short Fatty Acids-induced Release of GLP-1 in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Glostrup University Hospital, Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.

Detailed description

A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Tributyrin	a triglyceride containing three C4-acids
DIETARY_SUPPLEMENT	C8-diet oil	a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position
DIETARY_SUPPLEMENT	Olive oil	a triglyceride containing mostly three oleic acids
DIETARY_SUPPLEMENT	Carrot	mainly water and glucose

Timeline

• Start date: 2013-10-01
• Primary completion: 2013-12-01
• Completion: 2014-02-01
• First posted: 2014-10-15
• Last updated: 2014-10-15