NCT02264847

Human Chorionic Gonadotrophin & Trigger

Trigger or Not to Trigger? : An Answer for an Old Question

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In women being treated with medicines to help eggs to grow (called ovulation induction), The investigators wish to know whether adding medicines (called ovulation triggers) that help to release the egg (ovulation) would lead to more women having babies without causing harm compared with not giving them ovulation triggers.

Detailed description

Women will be treated with clomiphene citrate to help eggs to develop to additionally receive a medicine (urinary hCG) to trigger their release or to receive no additional treatment. the investigators tried to determine the benefits and harms of administering an ovulation trigger to anovulatory women receiving treatment with ovulation-inducing agents in comparison with spontaneous ovulation following ovulation induction. so we will have comparison between 2 groups, group 1 will receive clomiphene citrate and trigger ovulation by human chorionic gonadotrophin and group 2 will receive clomiphene citrate with no drug to trigger ovulation.

Conditions

• Ovulation Disorder

Interventions

Type	Name	Description
DRUG	Human chorionic gonadotrophin	Once a follicle reached more than 18 mm in size,women assigned to group (1) received 5,000 IU hCG trigger in the morning between 9 and 10 a.m. and the couple were advised to have intercourse the following night, about 36 hours later.
DRUG	clomiphene citrate alone	clomiphene citrate alone without hCG trigger

Timeline

• Start date: 2014-10-01
• Primary completion: 2017-04-01
• Completion: 2017-05-01
• First posted: 2014-10-15
• Last updated: 2017-02-08

Locations

1 site across 1 country: Egypt