NCT02262403

Hookworm Immune Regulation Project

Study of Immuno-regulatory Mechanisms Induced by Hookworm Infection

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Brugmann University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to characterize the regulatory immune response induced by hookworm in an infected Vietnamese rural population from the periphery of HCM, evolution after infection treatment and during potential naturally reinfection.

Detailed description

Population: 20 healthy adults (18-65 years) infected and non infected by Hookworm will be recruited and treated according to Good Clinical Practice recommendations. Allergy will be excluded by skin prick tests. Amount and phenotype of Treg will be explored at several time points. Subsequent culture with environmental antigen will be performed on cryopreserved cells.

Conditions

• Hookworm Infection

Interventions

Type	Name	Description
OTHER	Blood and feces sampling	Blood and feces samples will be examined after 14 days, 28 days, 3 months and 16 months. This will require blood and feces sampling. The study is therefore defined as 'interventional' rather than 'observational' as it includes acts outside the standard of care.

Timeline

• Start date: 2014-08-01
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2014-10-13
• Last updated: 2021-02-21

Locations

1 site across 1 country: Vietnam