NCT02261649

Impact of Cerebellar Mass Resection on Pain Processing

The Impact of Cerebellar Mass Resection on Pain Processing

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 24 (actual)
• Sponsor: Dana-Farber Cancer Institute · Academic / Other
• Sex: All
• Age: 6 Years – 38 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to evaluate how cerebellar resection surgery may affect pain sensation and the way the brain "reads" pain signals. By measuring brain activity in children and adolescents following surgery, the investigators hope to gain valuable information about pain processing in the brain.

Detailed description

This study is designed to test whether cerebellar resection surgery affects pain pathways in the brain. To participate a participant must (A) have had a cerebellar mass surgically removed, or (B) are a healthy volunteer with no history of pain disorders or mental illness. The study will involve sensory testing and brain imaging using magnetic resonance imaging (MRI) Sensory testing will be performed using a tub of cold water, as well as a contact thermode capable of delivering hot and cold temperatures. MRI brain scanning uses magnetic fields and radio waves to give pictures of the brain without using radiation.

Conditions

• Cerebellar Neoplasm

Interventions

Type	Name	Description
DEVICE	Medoc Advanced Medical Systems PATHWAY Model ATS	30 minutes of sensory testing using a contact thermal stimulator will measure thresholds for heat and cool detection, and threshold for hot and cold pain.
PROCEDURE	Cold water bath	The next 15 minutes of sensory testing will measure tolerance to having right or left hand in a tub of cold water. The participant will place their hand in cold water and leave it there for as long they can, even if it is uncomfortable. The participant can take their arm out if it gets too uncomfortable to leave it in.
DEVICE	MRI scanner	An MRI will be used to collect anatomical and functional images from patients and subjects. These data will be collected within a 1 hour block.
OTHER	Questionnaires	The surveys include questions about emotions, thoughts, and feelings. These surveys will be given before sensory testing and before the MRI scan. The parent or guardian will help to complete two surveys, and will complete one survey on his or her own. Questions can be skipped, and may be stopped at any time.

Timeline

• Start date: 2014-10-01
• Primary completion: 2017-04-01
• Completion: 2017-12-01
• First posted: 2014-10-10
• Last updated: 2018-02-01

Locations

1 site across 1 country: United States