NCT02255812

Taste Physiology in Healthy, Normal-weight Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.

Conditions

• Exploratory Behavior

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Single intragastric instillation of 200 mL tap water via nasogastric tube
DIETARY_SUPPLEMENT	Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube
DIETARY_SUPPLEMENT	Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube
DIETARY_SUPPLEMENT	Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube
DIETARY_SUPPLEMENT	Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube
DIETARY_SUPPLEMENT	Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Timeline

• Start date: 2013-03-01
• Primary completion: 2013-10-01
• Completion: 2013-10-01
• First posted: 2014-10-03
• Last updated: 2014-10-03

Locations

1 site across 1 country: Switzerland