NCT02254629

The Effects of Laxative-probiotic Sequential Treatment in the Irritable Bowel Syndrome Patients

The Effects of Laxative-probiotic Sequential Treatment on the Symptoms and Fecal Microbiota in the IBS Patients.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

the laxative-probiotic sequential treatment might reduce the symptoms of IBS and alter the fecal microbiota of the patients in a more robust manner .

Detailed description

Probiotics can regulate intestinal immunity, repair mucosal barrier, and reportedly exert therapeutic effects on IBS patients. The laxatives could also alter the gut microflora significantly, thus the laxative-probiotic sequential treatment might affect the symptoms and the composition of fecal microbiota in the IBS patients in a more robust manner .

Conditions

• Irritable Bowel Syndrome

Interventions

Type	Name	Description
DRUG	Probiotic Clostridium Butyricum	probiotic:2 tablets/ times, 3 times / day for 2 weeks
DRUG	Laxative Polyethylene Glycol	laxative：2000 ml.

Timeline

• Start date: 2014-07-01
• Primary completion: 2015-08-01
• Completion: 2016-07-01
• First posted: 2014-10-02
• Last updated: 2016-08-31

Locations

1 site across 1 country: China