NCT02254616

Hybrid Approach to Mirror Therapy and Transcranial Direct Current Stimulation for Stroke Recovery

Hybrid Approach to Mirror Therapy and Transcranial Direct Current Stimulation for Stroke Recovery: A Follow up Study on Brain Reorganization, Motor Performance of Upper Extremity, Daily Function, and Activity Participation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

We hypothesize that (1) the hybrid therapy will induce greater improvements on some health-related outcomes compared to other therapies; (2) such benefits will retain at 6-month follow-up; (3) better motor control and brain reorganization will be found in the hybrid therapy than the other therapies; (4) correlations will be found between brain activity and movement kinematics/health-related outcomes.

Detailed description

Chronic stroke participants will be recruited from the Chang Gung Memorial Hospital and then were randomly assigned to 1 of the 4 groups: MT+tDCS, MT+sham tDCS, MT, and CI groups. The participants in each group receive equivalent amounts of treatment. Analysis of covariance (ANCOVA), controlling for the pretest differences, will be separately performed for each outcome measure to test the effects of different intervention groups.

Conditions

• Cerebrovascular Accident

Interventions

Type	Name	Description
BEHAVIORAL	Mirror Therapy with tDCS	The MTtDCS group will receive a 20-minute tDCS at 1.5 mA current intensity per session followed by a 40-minute mirror therapy and 30-minute functional training during the first two weeks. Sixty-minute pure mirror therapy during the last 2 weeks, and followed by a 30-minute functional training.
BEHAVIORAL	Mirror Therapy with sham-tDCS	The MTtDCS(m) group will receive a 20-minute sham-tDCS per session followed by a 40-minute mirror therapy and 30-minute functional training during the first two weeks. Sixty-minute pure mirror therapy during the last 2 weeks, and followed by a 30-minute functional training.
BEHAVIORAL	Mirror Therapy	The MT group will receive a 60-minute MT per session followed by a 30-minute functional training.
BEHAVIORAL	Control Intervention	The CI group will receive a 60-minute conventional stroke rehabilitation training followed by a 30-minute functional training.

Timeline

• Start date: 2014-08-01
• Primary completion: 2017-07-31
• Completion: 2017-10-11
• First posted: 2014-10-02
• Last updated: 2019-02-15

Locations

4 sites across 1 country: Taiwan