NCT02252302

Exercise in Air Pollution and Lung Health in Asthmatics

The Effects of Inhaled Beta-2-Agonists and Air Pollution on Lung Function and Athletic Capacity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 19 Years – 40 Years
• Healthy volunteers: Accepted

Summary

When exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. Due to high breathing rates and volumes, physically active individuals are at particular risk of lung health impairment due to the high breathing rates and volumes. Greater doses of air pollutants reach deeper areas in the lungs where they can trigger asthma-symptoms. When treating these symptoms with inhaled beta-2-agonists the airways widen even more, allowing the air pollutants to reach even deeper areas of the lung. With this study the investigators investigate how inhaled beta-2-agonists affect athletic capacity and lung health in physically active asthmatics.

Conditions

• Exercise-induced Bronchoconstriction
• Air Pollution

Interventions

Type	Name	Description
OTHER	Rest (Sitting on chair)	Study participants will sit on a chair for 60min. This is to simulate physical resting condition.
OTHER	Cycling exercise	Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.
DRUG	Salbutamol inhalation	Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber.
DRUG	Placebo inhalation	Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber
OTHER	Diesel Exhaust Exposure	Participants will be exposed to PM2.5 of 300 μg/m3
OTHER	Filtered air	Participants will be breathing filtered air

Timeline

• Start date: 2015-05-01
• Primary completion: 2016-08-01
• Completion: 2021-05-01
• First posted: 2014-09-30
• Last updated: 2021-09-30

Locations

1 site across 1 country: Canada