NCT02246634

Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)

Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 282 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.

Detailed description

A phase II multicentre, interventional study to determine if additional staging at diagnosis with liver DW-MRI will diagnose more synchronous metastases than CT alone in patients with high risk colorectal cancer. Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local policy.

Conditions

• Colorectal Neoplasms
• Neoplasm Metastases
• Hepatic Neoplasms

Interventions

Type	Name	Description
OTHER	Diffusion Weighted MRI scan	Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local site policy.

Timeline

• Start date: 2014-08-01
• Primary completion: 2026-12-01
• Completion: 2031-12-01
• First posted: 2014-09-23
• Last updated: 2024-10-17

Locations

13 sites across 1 country: United Kingdom