NCT02245802

Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers

Multicenter Prospective Validation Study on the Prediction of In-hospital Mortality Using CU Prediction Model for Patients With Bleeding Peptic Ulcers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 785 (actual)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to validate CU prediction model on mortality for patients with high risk bleeding peptic ulcers after therapeutic endoscopy.

Detailed description

Despite advances in management of patients with bleeding peptic ulcers, mortality is still 10%. We previously reported a prediction score for ulcer bleeding related mortality developed from a local cohort. The risk factors for mortality included patients older than 70, presence of co-morbidity, more than one listed co-morbidity, hematemesis, SBP \< 100 mmHg, in-hospital bleeding, rebleeding, and need for surgery. Study objective This study aimed to validate the prediction of mortality among patients with bleeding peptic ulcers from different Asian countries. Method Consecutive patients with bleeding peptic ulcers who presented to the study centers in Hong Kong, Japan and Taiwan were recruited after successful primary endoscopic hemostasis. The baseline demographics, ulcer characteristics, the predictive factors, 30 days mortality, rebleeding, hospital stay and need of surgery were recorded. The accuracy of prediction for adverse events including mortality and rebleeding with the prediction risk scoring system would be analysed.

Conditions

• Bleeding Peptic Ulcer

Timeline

• Start date: 2010-08-01
• Primary completion: 2012-04-01
• Completion: 2012-04-01
• First posted: 2014-09-22
• Last updated: 2014-09-22

Locations

1 site across 1 country: China