NCT02245256

Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients

Perioperative Low-dose Dexmedetomidine Decreases Incidence of Delirium in Liver Transplant Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 217 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

To test the effect of low-dose dexmedetomidine for lowering the incidence of postoperative delirium in liver transplant patients in the ICU. Single center prospective randomized placebo controlled clinical trial 0.1mcg/kg/hr of dexmedetomidine or equivalent amount of saline infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery. Outcomes will be assessed up to 1 week or transfer to ward, whichever comes first.

Conditions

• Liver Transplantation

Interventions

Type	Name	Description
DRUG	Precedex	infusion of 0.1mcg/kg/hr of precedex
DRUG	placebo control	placebo

Timeline

• Start date: 2014-09-01
• Primary completion: 2018-01-01
• Completion: 2018-02-01
• First posted: 2014-09-19
• Last updated: 2019-09-25

Locations

1 site across 1 country: South Korea